Association between EXOC3L2 rs597668 polymorphism and Alzheimer's disease.

ABSTRACT:

Background

EXOC3L2 gene rs597668 polymorphism was identified to be significantly associated with Alzheimer's disease (AD) in Caucasian population. However, recent studies reported consistent and inconsistent results in Caucasian and Asian populations.

Aims

In order to assess this association, we performed a meta-analysis of rs597668 polymorphism using RevMan (v.5.1) software.

Methods

We searched PubMed and Google scholar databases and selected 4 independent publications, which included 16 independent studies. We conducted sensitivity analysis and evaluated the publication bias. In the end, we calculated the odds ratio (OR) using fixed effect model (Mantel-Haenszel).

Results

We observed significant association between rs597668 polymorphism and AD using allele mo

SUBMITTER: Shang H 

PROVIDER: S-EPMC6493651 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature