The Transcription Factor ERG Regulates Super-Enhancers Associated With an Endothelial-Specific Gene Expression Program.

ABSTRACT:

Rationale

The ETS (E-26 transformation-specific) transcription factor ERG (ETS-related gene) is essential for endothelial homeostasis, driving expression of lineage genes and repressing proinflammatory genes. Loss of ERG expression is associated with diseases including atherosclerosis. ERG's homeostatic function is lineage-specific, because aberrant ERG expression in cancer is oncogenic. The molecular basis for ERG lineage-specific activity is unknown. Transcriptional regulation of lineage specificity is linked to enhancer clusters (super-enhancers).

Objective

To investigate whether ERG regulates endothelial-specific gene expression via super-enhancers.

Methods and results

Chromatin immunoprecipitation with high-throughput sequencing in human umbilical vein endothelia

SUBMITTER: Kalna V 

PROVIDER: S-EPMC6493686 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature