Cardiovascular Effects of Treatment With the Ketone Body 3-Hydroxybutyrate in Chronic Heart Failure Patients.

ABSTRACT:

Background

Myocardial utilization of 3-hydroxybutyrate (3-OHB) is increased in patients with heart failure and reduced ejection fraction (HFrEF). However, the cardiovascular effects of increased circulating plasma-3-OHB levels in these patients are unknown. Consequently, the authors' aim was to modulate circulating 3-OHB levels in HFrEF patients and evaluate: (1) changes in cardiac output (CO); (2) a potential dose-response relationship between 3-OHB levels and CO; (3) the impact on myocardial external energy efficiency (MEE) and oxygen consumption (MVO₂); and (4) whether the cardiovascular response differed between HFrEF patients and age-matched volunteers.

Methods

Study 1: 16 chronic HFrEF patients (left ventricular ejection fraction: 37±3%) were randomized in a

SUBMITTER: Nielsen R 

PROVIDER: S-EPMC6493702 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature