Inhibition of Tityus serrulatus venom hyaluronidase affects venom biodistribution.

ABSTRACT:

Background

The hyaluronidase enzyme is generally known as a spreading factor in animal venoms. Although its activity has been demonstrated in several organisms, a deeper knowledge about hyaluronidase and the venom spreading process from the bite/sting site until its elimination from the victim's body is still in need. Herein, we further pursued the goal of demonstrating the effects of inhibition of T. serrulatus venom (TsV) hyaluronidase on venom biodistribution.

Methods and principal findings

We used technetium-99m radiolabeled Tityus serrulatus venom (99mTc-TsV) to evaluate the venom distribution kinetics in mice. To understand the hyaluronidase's role in the venom's biodistribution, 99mTc-TsV was immunoneutralized with specific anti-T.serrulatus hyaluronidase serum. Venom

SUBMITTER: Oliveira-Mendes BBR 

PROVIDER: S-EPMC6493768 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature