Regulation of the apical extension morphogenesis tunes the mechanosensory response of microvilliated neurons.

ABSTRACT: Multiple types of microvilliated sensory cells exhibit an apical extension thought to be instrumental in the detection of sensory cues. The investigation of the mechanisms underlying morphogenesis of sensory apparatus is critical to understand the biology of sensation. Most of what we currently know comes from the study of the hair bundle of the inner ear sensory cells, but morphogenesis and function of other sensory microvilliated apical extensions remain poorly understood. We focused on spinal sensory neurons that contact the cerebrospinal fluid (CSF) through the projection of a microvilliated apical process in the central canal, referred to as cerebrospinal fluid-contacting neurons (CSF-cNs). CSF-cNs respond to pH and osmolarity changes as well as mechanical stimuli associated with chan

SUBMITTER: Desban L 

PROVIDER: S-EPMC6493769 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature