The transcription factor POU3F2 regulates a gene coexpression network in brain tissue from patients with psychiatric disorders.

ABSTRACT: Schizophrenia and bipolar disorder are complex psychiatric diseases with risks contributed by multiple genes. Dysregulation of gene expression has been implicated in these disorders, but little is known about such dysregulation in the human brain. We analyzed three transcriptome datasets from 394 postmortem brain tissue samples from patients with schizophrenia or bipolar disorder or from healthy control individuals without a known history of psychiatric disease. We built genome-wide coexpression networks that included microRNAs (miRNAs). We identified a coexpression network module that was differentially expressed in the brain tissue from patients compared to healthy control individuals. This module contained genes that were principally involved in glial and neural cell genesis and glial c

SUBMITTER: Chen C 

PROVIDER: S-EPMC6494100 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature