Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions.

ABSTRACT: Genomic studies have identified hundreds of candidate genes near loci associated with risk for schizophrenia. To define candidates and their functions, we mutated zebrafish orthologs of 132 human schizophrenia-associated genes. We created a phenotype atlas consisting of whole-brain activity maps, brain structural differences, and profiles of behavioral abnormalities. Phenotypes were diverse but specific, including altered forebrain development and decreased prepulse inhibition. Exploration of these datasets identified promising candidates in more than 10 gene-rich regions, including the magnesium transporter cnnm2 and the translational repressor gigyf2, and revealed shared anatomical sites of activity differences, including the pallium, hypothalamus, and tectum. Single-cell RNA sequencing

SUBMITTER: Thyme SB 

PROVIDER: S-EPMC6494450 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature