Electro-Mechanical Conductance Modulation of a Nanopore Using a Removable Gate.

ABSTRACT: Ion channels form the basis of information processing in living cells by facilitating the exchange of electrical signals across and along cellular membranes. Applying the same principles to man-made systems requires the development of synthetic ion channels that can alter their conductance in response to a variety of external manipulations. By combining single-molecule electrical recordings with all-atom molecular dynamics simulations, we here demonstrate a hybrid nanopore system that allows for both a stepwise change of its conductance and a nonlinear current-voltage dependence. The conductance modulation is realized by using a short flexible peptide gate that carries opposite electric charge at its ends. We show that a constant transmembrane bias can position (and, in a later stage, remo

SUBMITTER: Zhao S 

PROVIDER: S-EPMC6494462 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature