Increasing antipsychotic dose for non response in schizophrenia.

ABSTRACT:

Background

Many people with schizophrenia do not reach a satisfactory clinical response with a standard dose of an initially prescribed antipsychotic drug. In such cases, clinicians face the dilemma of increasing the antipsychotic dose in order to enhance antipsychotic efficacy.

Objectives

To examine the efficacy of increasing antipsychotic dose compared to keeping the same dose in the treatment of people with schizophrenia who have not responded (as defined in the individual studies) to an initial antipsychotic drug trial. We also examine the adverse effects associated with such a procedure.

Search methods

We searched the Cochrane Schizophrenia Group Trials Register (10 June 2014, 6 October 2015, and 30 March 2017). We examined references of all included studies for

SUBMITTER: Samara MT 

PROVIDER: S-EPMC6494602 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature