Neonatal bloodspot DNA methylation patterns are associated with childhood weight status in the Healthy Families Project.

ABSTRACT:

Background

This study measured longitudinal DNA methylation dynamics at growth-related genes during childhood, and then tested whether DNA methylation at various stages of childhood was associated with obesity status.

Methods

Using neonatal bloodspot (n = 132) and matched childhood blood samples (n = 65), DNA methylation was quantified at a repetitive element (long interspersed nuclear element-1 (LINE-1)), two imprinted genes (IGF2, H19), and four non-imprinted genes (LEP, PPARA, ESR1, SREBF1) related to growth and adiposity. Logistic regression was used to test whether neonatal bloodspot DNA methylation at target genes was associated with log odds of obesity (Y/N) in children recruited from three age groups-12-24 months old (n = 40), 3-5 years of age (n = 40), and 10-12 yea

SUBMITTER: Kochmanski J 

PROVIDER: S-EPMC6494701 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature