A yield-cost tradeoff governs Escherichia coli's decision between fermentation and respiration in carbon-limited growth.

ABSTRACT: Living cells react to changes in growth conditions by re-shaping their proteome. This accounts for different stress-response strategies, both specific (i.e., aimed at increasing the availability of stress-mitigating proteins) and systemic (such as large-scale changes in the use of metabolic pathways aimed at a more efficient exploitation of resources). Proteome re-allocation can, however, imply significant biosynthetic costs. Whether and how such costs impact the growth performance are largely open problems. Focusing on carbon-limited E. coli growth, we integrate genome-scale modeling and proteomic data to address these questions at quantitative level. After deriving a simple formula linking growth rate, carbon intake, and biosynthetic costs, we show that optimal growth results from

SUBMITTER: Mori M 

PROVIDER: S-EPMC6494807 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature