Drug-like Fragments Inhibit agr-Mediated Virulence Expression in Staphylococcus aureus.

ABSTRACT: In response to the increasingly problematic emergence of antibiotic resistance, novel strategies for combating pathogenic bacteria are being investigated. Targeting the agr quorum sensing system, which regulates expression of virulence in Staphylococcus aureus, is one potentially useful approach for combating drug-resistant pathogens that has not yet been fully explored. A previously published study of a fragment screen resulted in the identification of five compound fragments that interact with the DNA-binding domain of the response regulator AgrA from S. aureus. We have analyzed the ability of these compounds to affect agr-mediated virulence gene expression in cultured S. aureus cells. Three of the compounds demonstrated the ability to reduce agr-driven transcription at the P2 and P3 pro

SUBMITTER: Bezar IF 

PROVIDER: S-EPMC6494831 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature