Correlation of hair and plasma efavirenz concentrations in HIV-positive South Africans.

ABSTRACT:

Background

Antiretroviral concentrations in hair provide a longer window of drug detection and are useful for measuring longer-term drug exposure. Efavirenz is an important component of first-line treatment in resource-limited settings, but its concentrations in hair have not been well studied.

Methods

This study is a supplementary to a randomised controlled trial of an adherence intervention using an electronic adherence measuring device. Hair and plasma samples were collected from human immunodeficiency virus-positive patients in Cape Town, South Africa. Previously validated liquid chromatography tandem mass spectrometry methods were used to measure efavirenz concentrations in the collected hair and plasma samples. CYP2B6 genotyping of participants was also performe

SUBMITTER: Johnston J 

PROVIDER: S-EPMC6494950 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature