Modeling Conformationally Flexible Proteins With X-ray Scattering and Molecular Simulations.

ABSTRACT: Proteins and protein complexes with high conformational flexibility participate in a wide range of biological processes. These processes include genome maintenance, gene expression, signal transduction, cell cycle regulation, and many others. Gaining a structural understanding of conformationally flexible proteins and protein complexes is arguably the greatest problem facing structural biologists today. Over the last decade, some progress has been made toward understanding the conformational flexibility of such systems using hybrid approaches. One particularly fruitful strategy has been the combination of small-angle X-ray scattering (SAXS) and molecular simulations. In this article, we provide a brief overview of SAXS and molecular simulations and then discuss two general approaches for c

SUBMITTER: Powers KT 

PROVIDER: S-EPMC6495069 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature