Vitamin D is Not a Protective Factor in ALS.

ABSTRACT:

Aims

Vitamin D deficiency has been associated with poorer prognosis in ALS. Better understanding of the role of vitamin D in ALS is needed to determine whether trials of systematic supplementation are justified. Our aim was to report vitamin D levels during the course of ALS and to evaluate its relationship with clinical parameters at diagnosis and with disease progression.

Methods

We prospectively collected vitamin D serum concentrations from 125 consecutive ALS patients. Cox proportional hazard models analyzed the relationship between vitamin D concentrations, clinical parameters, and survival.

Results

The mean vitamin D concentration was below our laboratory's lower limit of normal (P < 0.0001) and did not change during the course of the disease. The concentrations

SUBMITTER: Blasco H 

PROVIDER: S-EPMC6495158 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature