Major Stressful Life Events and Risk of Developing Lung Cancer: A Case-Control Study.

ABSTRACT:

Background

Lung cancer is the leading cause of cancer-related mortality and is strongly linked with smoking. We sought to determine whether major stressful life events (e.g. divorce) are also a risk factor for developing lung cancers.

Methods

We performed a matched case-control study. Cases (CA) were lung cancer patients diagnosed within the previous 12 months. Controls (CO) were patients without a prior history of malignancy. Data on major stressful life events were collected using the modified Holmes-Rahe stress scale. The primary endpoint was the odds of having a major stressful life event between CA and CO. A sample of 360 patients (CA = 120, CO = 240) was needed to achieve 80% power to detect an odds ratio (OR) of 2.00 versus the alternative of equal odds using χ

SUBMITTER: Jafri SH 

PROVIDER: S-EPMC6495441 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature