Short stature-related single-nucleotide polymorphism (SNP) activates endothelial repair activity in elderly Japanese.

ABSTRACT:

Background

Hypertension and atherosclerosis are bidirectionally related, while platelet count could serve as an indicator of endothelial repair. Therefore, high platelet counts could be associated with hypertension by indicating more intense endothelial repair activity. Furthermore, short stature has been shown to constitute a risk of atherosclerosis. Since inflammation-related single-nucleotide polymorphism (SNP (rs3782886)) is reportedly associated with myocardial infarction and short stature, rs3782886 could be associated with a high platelet count and thus more intense endothelial repair activity.

Methods

We conducted a cross-sectional study of 988 elderly Japanese who participated in a general health check-up. Short stature was defined as a height of at or under the 25t

SUBMITTER: Shimizu Y 

PROVIDER: S-EPMC6495505 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature