Identification of biomarkers in macrophages of atherosclerosis by microarray analysis.

ABSTRACT:

Background

Atherosclerotic cardiovascular disease (ASCVD) refers to a series of diseases caused by atherosclerosis (AS). It is one of the most important causes of death worldwide. According to the inflammatory response theory, macrophages play a critical role in AS. However, the potential targets associated with macrophages in the development of AS are still obscure. This study aimed to use bioinformatics tools for screening and identifying molecular targets in AS macrophages.

Methods

Two expression profiling datasets (GSE7074 and GSE9874) were obtained from the Gene Expression Omnibus dataset, and differentially expressed genes (DEGs) between non-AS macrophages and AS macrophages were identified. Functional annotation of the DEGs was performed by analyzing the Gene Ontology

SUBMITTER: Huang HM 

PROVIDER: S-EPMC6495566 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature