A quantitative method for evaluating cortical responses to electrical stimulation.

ABSTRACT:

Background

Electrical stimulation of the cortex using subdurally implanted electrodes can causally reveal structural connectivity by eliciting cortico-cortical evoked potentials (CCEPs). While many studies have demonstrated the potential value of CCEPs, the methods to evaluate them were often relatively subjective, did not consider potential artifacts, and did not lend themselves to systematic scientific investigations.

New method

We developed an automated and quantitative method called SIGNI (Stimulation-Induced Gamma-based Network Identification) to evaluate cortical population-level responses to electrical stimulation that minimizes the impact of electrical artifacts. We applied SIGNI to electrocorticographic (ECoG) data from eight human subjects who were implanted with a

SUBMITTER: Crowther LJ 

PROVIDER: S-EPMC6495652 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature