In silico analysis of molecular mechanisms of legume lectin-induced apoptosis in cancer cells.

ABSTRACT:

Objectives

The legume lectin family, one of the most extensively studied plant lectin families, has received increasing attention for the remarkable anti-tumor activities of its members for binding specific cancer cell surface glycoconjugates. MicroRNAs, a class of small, non-coding RNAs, control translation and stability of mRNAs at post-transcriptional and translational levels. To date, accumulating evidence has revealed that microRNAs are involved in progression of a number of human diseases, especially cancers. However, the molecular manners of microRNA-modulated apoptosis in legume lectin-treated cancer cells are still under investigation.

Materials and methods

We performed in silico analyses to study the interactions between three typical legume lectins (ConA, SFL and

SUBMITTER: Shi Z 

PROVIDER: S-EPMC6495806 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature