Histamine promotes locomotion recovery after spinal cord hemisection via inhibiting astrocytic scar formation.

ABSTRACT:

Aim

This study investigated whether histamine could play a protective role in pathophysiological response of spinal cord injury (SCI) and regulate the glial scar formation.

Methods

Functional assessment and histological analyses were performed to investigate the effect of histamine after SCI. Histidine decarboxylase knockout (HDC(-/-)) mice were used to confirm the action of histamine. Selective antagonists for H1 and H2 receptors were utilized in vivo and in vitro to verify the functional properties of histamine on astrogliosis.

Results

The local administration of histamine significantly attenuated the tissue damage and glial scar formation after SCI. In particular, the astrogliosis and neurocan expression found around the lesion were significantly suppressed by hist

SUBMITTER: Zhao YY 

PROVIDER: S-EPMC6495821 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature