Inhibition of Vesicular Transport Influences Fungal Susceptibility to Fluconazole.

ABSTRACT: Fungal infections pose a substantial threat to the human population. They can cause either mild and relatively harmless infections or invasive and often lethal diseases in patients with a weakened immune system. The majority of these human fungal infections are caused by Candida species. The limited amount of available therapies, together with the development of resistance against these drugs, strongly emphasizes the need for novel therapeutic strategies. As it is quite time-consuming to introduce completely new drugs to the market, potentiating the efficacy of existing drugs would be a better strategy. Therefore, it is important to identify cellular pathways involved in the development of drug resistance. We found that vesicular transport is involved in fungal susceptibility to the most w

SUBMITTER: Demuyser L 

PROVIDER: S-EPMC6496062 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature