Identification of novel caspase/autophagy-related gene switch to cell fate decisions in breast cancers.

ABSTRACT:

Objectives

Caspases, a family of cysteine proteases with unique substrate specificities, contribute to apoptosis, whereas autophagy-related genes (ATGs) regulate cytoprotective autophagy or autophagic cell death in cancer. Accumulating evidence has recently revealed underlying mechanisms of apoptosis and autophagy; however, their intricate relationships still remain to be clarified. Identification of caspase/ATG switches between apoptosis and autophagy may address this problem.

Materials and methods

Identification of caspase/ATG switches was carried out using a series of elegant systems biology & bioinformatics approaches, such as network construction, hub protein identification, microarray analyses, targeted microRNA prediction and molecular docking.

Results

We compu

SUBMITTER: Fu LL 

PROVIDER: S-EPMC6496286 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature