Network-based identification of key proteins involved in apoptosis and cell cycle regulation.

ABSTRACT:

Objectives

Cancer cells differ from normal body cells in their ability to divide indefinitely and to evade programmed cell death. Crosstalk between apoptosis and cell cycle processes promotes balance between proliferation and death, and limits population growth and survival of cells. However, intricate relationships between them and how they are able to manipulate the fate of cancer cells still remain to be clarified. Identification of key factors involved in both apoptosis and cell cycle regulation may help to address this problem.

Materials and methods

Identification of such key proteins was carried out, using a series of bioinformatics methods, such as network construction and key protein identification.

Results

In this study, we computationally constructed human a

SUBMITTER: Wu L 

PROVIDER: S-EPMC6496515 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature