Identification of microRNA-regulated autophagic pathways in plant lectin-induced cancer cell death.

ABSTRACT:

Objectives

Plant lectins, carbohydrate-binding proteins of non-immune origin, have recently been reported to induce programmed cell death (including apoptosis and autophagy) in many types of cancer cells. MicroRNAs (miRNAs), small, non-coding endogenous RNAs, ~22 nucleotides (nt) in length, have been well characterized to play essential roles in regulation of the autophagy process in cancer; however, how these miRNAs regulate autophagic pathways in plant lectin-induced cancer cells, still remains an enigma.

Materials and methods

Identification of microRNA-regulated autophagic pathways was carried out using a series of elegant systems - biology and bioinformatics approaches, such as network construction, hub protein identification, targeted microRNA prediction, microarray ana

SUBMITTER: Fu LL 

PROVIDER: S-EPMC6496687 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature