Transforming growth factor-beta1 regulates the fate of cultured spinal cord-derived neural progenitor cells.

ABSTRACT:

Objectives

We have evaluated the physiological roles of transforming growth factor-beta1 (TGF-beta1) on differentiation, migration, proliferation and anti-apoptosis characteristics of cultured spinal cord-derived neural progenitor cells.

Methods

We have used neural progenitor cells that had been isolated and cultured from mouse spinal cord tissue, and we also assessed the relevant reaction mechanisms using an activin-like kinase (ALK)-specific inhibitory system including an inhibitory RNA, and found that it involved potential signalling molecules such as phosphatidylinositol-3-OH kinase (PI3K)/Akt and mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK1/2).

Results and conclusions

Transforming growth factor-beta1-mediated cell population

SUBMITTER: Park SM 

PROVIDER: S-EPMC6496837 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature