Mechanism of action of cytotoxic compounds from the seeds of Euphorbia lathyris.

ABSTRACT:

Background

The seeds of Euphorbia lathyris are used in traditional Chinese medicines for the treatment of various medical conditions. E. lathyris contains many natural diterpenes with a lathyrane skeleton.

Purpose and study design

Five lathyrane-type diterpenoids named Euphorbia factors L₁, L₂, L₃, L₈, and L₉ (1-5), were investigated for cytotoxicity against A549, MDA-MB-231, KB, and MCF-7 cancer cell lines and the KB-VIN multidrug resistant (MDR) cancer cell line. Also, a tetraol derivative (6) of Euphorbia factor L₂ (2) was synthesized to assess the effect of hydroxy moieties.

Methods

An ethanolic extract of seeds of Euphorbia lathyris was prepared and separated into petroleum ether, EtOAc, n-butanol,

SUBMITTER: Teng YN 

PROVIDER: S-EPMC6496940 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature