A Common Embryonic Origin of Stem Cells Drives Developmental and Adult Neurogenesis.

ABSTRACT: New neurons arise from quiescent adult neural progenitors throughout life in specific regions of the mammalian brain. Little is known about the embryonic origin and establishment of adult neural progenitors. Here, we show that Hopx⁺ precursors in the mouse dentate neuroepithelium at embryonic day 11.5 give rise to proliferative Hopx⁺ neural progenitors in the primitive dentate region, and they, in turn, generate granule neurons, but not other neurons, throughout development and then transition into Hopx⁺ quiescent radial glial-like neural progenitors during an early postnatal period. RNA-seq and ATAC-seq analyses of Hopx⁺ embryonic, early postnatal, and adult dentate neural progenitors further reveal common molecular and epigenetic signatures and

SUBMITTER: Berg DA 

PROVIDER: S-EPMC6496946 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature