Novel Development of Parafoveal Capillary Density Deviation Mapping using an Age-Group and Eccentricity Matched Normative OCT Angiography Database.

ABSTRACT:

Purpose

We evaluate the impact of age and signal strength index (SSI) on foveal avascular zone (FAZ) metrics and parafoveal capillary density measured using optical coherence tomography angiography (OCT-A), and propose a deviation mapping approach that accounts for age-group, SSI, eccentricity, and variation in FAZ size.

Methods

Parafoveal OCT-A with full vascular layer was obtained for 261 controls and four patients with retinal abnormalities. Parafoveal capillary densities were measured within eight consecutive 200-μm wide annuli from the FAZ border. In controls, the impacts of age and SSI on FAZ metrics and parafoveal capillary density were evaluated. Deviation maps highlighting regions with density at the lower and upper tails of the age-group and eccentricity matched di

SUBMITTER: Andrade Romo JS 

PROVIDER: S-EPMC6496970 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature