FSEM: Functional Structural Equation Models for Twin Functional Data.

ABSTRACT: The aim of this paper is to develop a novel class of functional structural equation models (FSEMs) for dissecting functional genetic and environmental effects on twin functional data, while characterizing the varying association between functional data and covariates of interest. We propose a three-stage estimation procedure to estimate varying coefficient functions for various covariates (e.g., gender) as well as three covariance operators for the genetic and environmental effects. We develop an inference procedure based on weighted likelihood ratio statistics to test the genetic/environmental effect at either a fixed location or a compact region. We also systematically carry out the theoretical analysis of the estimated varying functions, the weighted likelihood ratio statistics, and the

SUBMITTER: Luo S 

PROVIDER: S-EPMC6497081 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature