Circulating Biomarkers Predicting Longitudinal Changes in Left Ventricular Structure and Function in a General Population.

ABSTRACT: Background Serial imaging studies in the general population remain important to evaluate the usefulness of pathophysiologically relevant biomarkers in predicting progression of left ventricular (LV) remodeling and dysfunction. Here, we assessed in a general population whether these circulating biomarkers at baseline predict longitudinal changes in LV structure and function. Methods and Results In 592 participants (mean age, 50.8 years; 51.4% women; 40.5% hypertensive), we derived echocardiographic indexes reflecting LV structure and function at baseline and after 4.7 years. At baseline, we measured alkaline phosphatase, markers of collagen turnover (procollagen type I, C-terminal telopeptide, matrix metalloproteinase-1) and high-sensitivity cardiac troponin T. We regressed longitudinal cha

SUBMITTER: Cauwenberghs N 

PROVIDER: S-EPMC6497333 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature