Ruthenium-Catalyzed Redox Isomerizations inside Living Cells.

ABSTRACT: Tailored ruthenium(IV) complexes can catalyze the isomerization of allylic alcohols into saturated carbonyl derivatives under physiologically relevant conditions, and even inside living mammalian cells. The reaction, which involves ruthenium-hydride intermediates, is bioorthogonal and biocompatible, and can be used for the "in cellulo" generation of fluorescent and bioactive probes. Overall, our research reveals a novel metal-based tool for cellular intervention, and comes to further demonstrate the compatibility of organometallic mechanisms with the complex environment of cells.

SUBMITTER: Vidal C 

PROVIDER: S-EPMC6497367 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature