Effect of overnight smoking abstinence on a marker for microglial activation: a [¹¹C]DAA1106 positron emission tomography study.

ABSTRACT:

Rationale

Microglia are the main immune cells in the central nervous system and participate in neuroinflammation. When activated, microglia express increased levels of the translocator protein 18 kDa (TSPO), thereby making TSPO availability a marker for neuroinflammation. Using positron emission tomography (PET) scanning, our group recently demonstrated that smokers in the satiated state had 16.8% less binding of the radiotracer [¹¹C]DAA1106 (a radioligand for TSPO) in the brain than nonsmokers.

Objectives

We sought to determine the effect of overnight smoking abstinence on [¹¹C]DAA1106 binding in the brain.

Methods

Forty participants (22 smokers and 18 nonsmokers) completed the study (at one of two sites) and had usable data, which included imag

SUBMITTER: Brody AL 

PROVIDER: S-EPMC6497451 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature