Molecular Characterization of Prostate Cancer with Associated Gleason Score Using Mass Spectrometry Imaging.

ABSTRACT: Diagnosis of prostate cancer is based on histologic evaluation of tumor architecture using a system known as the "Gleason score." This diagnostic paradigm, while the standard of care, is time-consuming, shows intraobserver variability, and provides no information about the altered metabolic pathways, which result in altered tissue architecture. Characterization of the molecular composition of prostate cancer and how it changes with respect to the Gleason score (GS) could enable a more objective and faster diagnosis. It may also aid in our understanding of disease onset and progression. In this work, we present mass spectrometry imaging for identification and mapping of lipids and metabolites in prostate tissue from patients with known prostate cancer with GS from 6 to 9. A gradient of chan

SUBMITTER: Randall EC 

PROVIDER: S-EPMC6497547 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature