Effects of metformin and alogliptin on body composition in people with type 2 diabetes.

ABSTRACT:

Aims/introduction

The aim of the present study was to investigate the effects of metformin and a dipeptidyl peptidase-4 inhibitor, alogliptin, on body composition in a 12-week randomized add-on trial in Japanese participants with type 2 diabetes.

Materials and methods

A total of 84 participants with poorly controlled type 2 diabetes undergoing antidiabetic therapy were randomly assigned to receive alogliptin (25 mg, once daily) or metformin (1,000 mg, twice daily) for 12 weeks. The primary efficacy end-point was body composition. The secondary end-points included factors associated with decreased bodyweight.

Results

Compared with the baseline values, alogliptin significantly increased bodyweight (66.5 ± 19.2 to 67.6 ± 19.3 kg), body mass index (BMI; 25.4 ± 6.1 to 25.8

SUBMITTER: Takeshita Y 

PROVIDER: S-EPMC6497598 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature