Contribution of pancreatic α-cell function to insulin sensitivity and glycemic variability in patients with type 1 diabetes.

ABSTRACT:

Aims/introduction

To evaluate the contribution of pancreatic α-cell function to the dawn phenomenon, insulin sensitivity, hepatic glucose uptake and glycemic variability in patients with type 1 diabetes.

Materials and methods

In 40 patients with type 1 diabetes, arginine stimulation tests were carried out, and the area under the curve (AUC) of glucagon was measured using radioimmunoassays (AUC_{glc RIA} ) and enzyme-linked immunosorbent assays (AUC_{glc ELISA} ). The ratio of the insulin dose delivered by an artificial pancreas to maintain euglycemia between 04.00 and 08.00 hours or between 00.00 and 04.00 hours was measured as the dawn index. The glucose infusion rate and hepatic glucose uptake were measured using hyperinsulinemic eugly

SUBMITTER: Takahashi N 

PROVIDER: S-EPMC6497601 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature