A Genetic Investigation of the Well-Being Spectrum.

ABSTRACT: The interrelations among well-being, neuroticism, and depression can be captured in a so-called well-being spectrum (3-phenotype well-being spectrum, 3-WBS). Several other human traits are likely linked to the 3-WBS. In the present study, we investigate how the 3-WBS can be expanded. First, we constructed polygenic risk scores for the 3-WBS and used this score to predict a series of traits that have been associated with well-being in the literature. We included information on loneliness, big five personality traits, self-rated health, and flourishing. The 3-WBS polygenic score predicted all the original 3-WBS traits and additionally loneliness, self-rated health, and extraversion (R² between 0.62% and 1.58%). Next, using LD score regression, we calculated genetic correlations be

SUBMITTER: Baselmans BML 

PROVIDER: S-EPMC6497622 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature