The Effect of Ganoderma Microsporum immunomodulatory proteins on alleviating PM_2.5-induced inflammatory responses in pregnant rats and fine particulate matter-induced neurological damage in the offsprings.

ABSTRACT: Fine particulate matter 2.5 (PM_2.5) induces free radicals and oxidative stress in animals, leading to a range of illnesses. In this study, Ganoderma Microsporum immunomodulatory (GMI) proteins were administered to alleviate PM_2.5-induced inflammatory responses in mother rats, and PM_2.5-induced inflammatory responses and neurological damage in their offspring. The results suggested that GMI administration decreased the risk of neurological disorders in mother rats and their offspring by reducing the white blood cell count, lessening inflammatory responses and PM_2.5-induced memory impairment, and preventing dendritic branches in the hippocampi from declining and microRNAs from PM_2.5-induced modulation.

SUBMITTER: Tseng CY 

PROVIDER: S-EPMC6497649 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature