In Vivo Toxicity Evaluation of PEGylated CuInS₂/ZnS Quantum Dots in BALB/c Mice.

ABSTRACT: In recent years, quantum dots (QDs) have emerged as a potential contrast agent for bioimaging due to their bright luminescence and excellent photostability. However, the wide use of QDs in vivo has been limited due to underlying toxicity caused by leakage of heavy metals. Although non-cadmium QDs have been developed to resolve this issue, a comprehensive understanding of the toxicity of these newly developed QDs remains elusive. In this study, we administered PEGylated copper indium sulfide/zinc sulfide (CuInS₂/ZnS), which are typical non-cadmium QDs, and analyzed the long-term effects of these nanoparticles in BALB/c mice. Body weight, hematology, blood biochemistry, organ histology, and biodistribution were examined at different time points. We found no significant diff

SUBMITTER: Zou W 

PROVIDER: S-EPMC6497768 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature