Analyses of the Global Multilocus Genotypes of the Human Pathogenic Yeast Candida tropicalis.

ABSTRACT: Candida tropicalis is a globally distributed human pathogenic yeast, especially prevalent in tropical and sub-tropical regions. Over the last several decades, a large number of studies have been published on the genetic diversity and molecular epidemiology of C. tropicalis from different parts of the world. However, the global pattern of genetic variation remains largely unknown. Here we analyzed the published multilocus sequence data at six loci for 876 isolates from 16 countries representing five continents. Our results showed that 280 of the 2677 (10.5%) analyzed nucleotides were polymorphic, resulting in a mean of 82 (a range of 38-150) genotypes per locus and a total of 633 combined diploid sequence types (DSTs). Among these, 93 combined DSTs were shared by 336 strains,

SUBMITTER: Wu JY 

PROVIDER: S-EPMC6497803 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature