Temporal association of rotavirus vaccination and genotype circulation in South Africa: Observations from 2002 to 2014.

ABSTRACT:

Background

Rotavirus vaccination has reduced diarrhoeal morbidity and mortality globally. The monovalent rotavirus vaccine was introduced into the public immunization program in South Africa (SA) in 2009 and led to approximately 50% reduction in rotavirus hospitalization in young children. The aim of this study was to investigate the rotavirus genotype distribution in SA before and after vaccine introduction.

Materials and methods

In addition to pre-vaccine era surveillance conducted from 2002 to 2008 at Dr George Mukhari Hospital (DGM), rotavirus surveillance among children <5 years hospitalized for acute diarrhoea was established at seven sentinel sites in SA from April 2009 to December 2014. Stool specimens were screened by enzyme immunoassay and rotavirus positive specim

SUBMITTER: Page NA 

PROVIDER: S-EPMC6497815 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature