Ontology highlight
ABSTRACT:
SUBMITTER: Cong X
PROVIDER: S-EPMC6497948 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20190304 17
The fish olfactory receptor ORA family is orthologous to the mammalian vomeronasal receptors type 1. It consists of six highly conserved chemosensory receptors expected to be essential for survival and communication. We deorphanized the zebrafish ORA family in a heterologous cell system. The six receptors responded specifically to lithocholic acid (LCA) and closely related C<sub>24</sub> 5β-bile acids/salts. LCA attracted zebrafish as strongly as food in behavioral tests, whereas the less potent ...[more]