In vitro Mycobacterial Growth Inhibition in South Korean Adults With Latent TB Infection.

ABSTRACT: Background: It is important to understand the ability to inhibit mycobacterial growth in healthy adults who would have been Bacillus Calmette-Guérin (BCG) vaccinated in childhood as this group will be the potential target population for novel booster TB vaccine trials. In this study we investigated not only the long-term immunity induced by childhood BCG vaccination but also protective immunity in terms of the ability to inhibit mycobacterial growth in those who were BCG vaccinated in childhood, with evidence of recent or remote TB infection. Methods: We measured the baseline immune response using a functional mycobacterial growth inhibition assay (MGIA) as a novel approach and an intracellular cytokine staining (ICS) assay as a reference approach in healthy adults, with diff

SUBMITTER: Lee H 

PROVIDER: S-EPMC6497970 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature