HIV Controllers Have Low Inflammation Associated with a Strong HIV-Specific Immune Response in Blood.

ABSTRACT: HIV controllers (HIC) maintain control of HIV replication without combined antiretroviral treatment (cART). The mechanisms leading to virus control are not fully known. We used gene expression and cellular analyses to compare HIC and HIV-1-infected individuals under cART. In the blood, HIC are characterized by a low inflammation, a downmodulation of natural killer inhibitory cell signaling, and an upregulation of T cell activation gene expression. This balance that persists after stimulation of cells with HIV antigens was consistent with functional analyses showing a bias toward a Th1 and cytotoxic T cell response and a lower production of inflammatory cytokines. Taking advantage of the characterization of HIC based upon their CD8+ T lymphocyte capacity to suppress HIV-infection, we show h

SUBMITTER: Hocini H 

PROVIDER: S-EPMC6498051 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature