Gas-Shearing Fabrication of Multicompartmental Microspheres: A One-Step and Oil-Free Approach.

ABSTRACT: Multicompartmental microparticles (MCMs) have attracted considerable attention in biomedical engineering and materials sciences, as they can carry multiple materials in the separated phases of a single particle. However, the robust fabrication of monodisperse, highly compartmental MCMs at the micro- and nanoscales remains challenging. Here, a simple one-step and oil-free process, based on the gas-flow-assisted formation of microdroplets ("gas-shearing"), is established for the scalable production of monodisperse MCMs. By changing the configuration of the needle system and gas flow in the spray ejector device, the oil-free gas-shearing process easily allows the design of microparticles consisting of two, four, six, and even eight compartments with a precise control over the properties of ea

SUBMITTER: Tang G 

PROVIDER: S-EPMC6498303 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature