Impact of inflammatory signaling on radiation biodosimetry: mouse model of inflammatory bowel disease.

ABSTRACT:

Background

Ionizing Radiation (IR) is a known pro-inflammatory agent and in the process of development of biomarkers for radiation biodosimetry, a chronic inflammatory disease condition could act as a confounding factor. Hence, it is important to develop radiation signatures that can distinguish between IR-induced inflammatory responses and pre-existing disease. In this study, we compared the gene expression response of a genetically modified mouse model of inflammatory bowel disease (Il10^-/-) with that of a normal wild-type mouse to potentially develop transcriptomics-based biodosimetry markers that can predict radiation exposure in individuals regardless of pre-existing inflammatory condition.

Results

Wild-type (WT) and Il10^-/- mice were exposed to wh

SUBMITTER: Mukherjee S 

PROVIDER: S-EPMC6498469 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature