Molecular characterization of enterovirus-A71 in children with acute flaccid paralysis in the Philippines.

ABSTRACT:

Background

Several inactivated enterovirus-A71 (EV-A71) vaccines are currently licensed in China; however, the development of additional EV-A71 vaccines is ongoing, necessitating extensive analysis of the molecular epidemiology of the virus worldwide. Until 2012, laboratory confirmation of EV-A71 for hand, foot, and mouth disease (HFMD) and other associated diseases had not occurred in the Philippines. Because EV-A71 has been linked with cases of acute flaccid paralysis (AFP), AFP surveillance is one strategy for documenting its possible circulation in the country. To expand current knowledge on EV-A71, molecular epidemiologic analysis and genetic characterization of EV-A71 isolates were performed in this study.

Methods

A retrospective study was performed to identify and cha

SUBMITTER: Apostol LN 

PROVIDER: S-EPMC6498601 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature