Nutrigenomics as a tool to study the impact of diet on aging and age-related diseases: the Drosophila approach.

ABSTRACT: Aging is a complex phenomenon caused by the time-dependent loss of cellular homeodynamics and consequently of physiological organismal functions. This process is affected by both genetic and environmental (e.g., diet) factors, as well as by their constant interaction. Consistently, deregulation of nutrient sensing and signaling pathways is considered a hallmark of aging. Nutrigenomics is an emerging scientific discipline that studies changes induced by diet on the genome and thus it considers the intersection of three topics, namely health, diet, and genomics. Model organisms, such as the fruit fly Drosophila melanogaster, have been successfully used for in vivo modeling of higher metazoans aging and for nutrigenomic studies. Drosophila is a well-studied organism with sophist

SUBMITTER: Evangelakou Z 

PROVIDER: S-EPMC6498619 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature