Regulation of Plasmodium sporozoite motility by formulation components.

ABSTRACT:

Background

The protective efficacy of the most promising malaria whole-parasite based vaccine candidates critically depends on the parasite's potential to migrate in the human host. Key components of the parasite motility machinery (e.g. adhesive proteins, actin/myosin-based motor, geometrical properties) have been identified, however the regulation of this machinery is an unknown process.

Methods

In vitro microscopic live imaging of parasites in different formulations was performed and analysed, with the quantitative analysis software SMOOT_{In vitro}, their motility; their adherence capacity, movement pattern and velocity during forward locomotion.

Results

SMOOT_{In vitro} enabled the detailed analysis of the regulation of the motility machinery of P

SUBMITTER: de Korne CM 

PROVIDER: S-EPMC6498664 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature