Dataset Information

Do pathologists agree with each other on the histological assessment of pT1b oesophageal adenocarcinoma?

ABSTRACT:

Background

In early (T1) oesophageal adenocarcinoma (OAC), the histological profile of an endoscopic resection specimen plays a pivotal role in the prediction of lymph node metastasis and the potential need for oesophagectomy with lymphadenectomy.

Objective

To evaluate the inter-observer agreement of the histological assessment of submucosal (pT1b) OAC.

Methods

Surgical and endoscopic resection specimens with pT1b OAC were independently reviewed by three gastrointestinal pathologists. Agreement was determined by intraclass correlation coefficient for continuous variables, and Fleiss' kappa (κ) for categorical variables. Bland-Altman plots of the submucosal invasion depth were made.

Results

Eighty-five resection specimens with pT1b OAC were evaluated. The agreement was good for differentiation grade (κ=0.77, 95% confidence interval (CI) 0.68-0.87), excellent for lymphovascular invasion (κ=0.88, 95% CI 0.76-1.00) and moderate for submucosal invasion depth using the Paris and Pragmatic classifications (κ=0.60, 95% CI 0.49-0.72 and κ=0.42, 95% CI 0.33-0.51, respectively). Systematic mean differences between pathologists were detected for the measurement of submucosal invasion depth, ranging from 297 µm to 602 µm.

Conclusions

A substantial discordance was found between pathologists for the measurement of submucosal invasion depth in pT1b OAC. Differences may lead to an over- or underestimation of the lymph node metastasis risk, with grave implications for the treatment strategy. Review by a second gastrointestinal pathologist is recommended to improve differentiating between a favourable and an unfavourable histological profile.

SUBMITTER: Gotink AW

PROVIDER: S-EPMC6498808 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Publications

Do pathologists agree with each other on the histological assessment of pT1b oesophageal adenocarcinoma?

Gotink Annieke W AW Ten Kate Fiebo Jc FJ Doukas Michael M Wijnhoven Bas Pl BP Bruno Marco J MJ Looijenga Leendert Hj LH Koch Arjun D AD Biermann Katharina K

United European gastroenterology journal 20181206 2

<h4>Background</h4>In early (T1) oesophageal adenocarcinoma (OAC), the histological profile of an endoscopic resection specimen plays a pivotal role in the prediction of lymph node metastasis and the potential need for oesophagectomy with lymphadenectomy.<h4>Objective</h4>To evaluate the inter-observer agreement of the histological assessment of submucosal (pT1b) OAC.<h4>Methods</h4>Surgical and endoscopic resection specimens with pT1b OAC were independently reviewed by three gastrointestinal pa ...[more]

PMID: 31080611

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Project description:PurposeTo validate prostate tissue composition measured using hybrid multi-dimensional MRI (HM-MRI) by comparing with reference standard (ground truth) results from pathologists' interpretation of clinical histopathology slides following whole mount prostatectomy.Materials and methods36 prospective participants with biopsy-confirmed prostate cancer underwent 3 T MRI prior to radical prostatectomy. Axial HM-MRI was acquired with all combinations of echo times of 57, 70, 150, 200 ms and b-values of 0, 150, 750, 1500 s/mm2 and data were fitted using a 3-compartment signal model using custom software to generate volumes for each tissue component (stroma, epithelium, lumen). Three experienced genitourinary pathologists independently as well as in consensus reviewed each histology image and provide an estimate of percentage of epithelium and lumen for regions-of-interest corresponding to MRI (n = 165; 64 prostate cancers and 101 benign tissue). Agreement statistics using total deviation index (TDI0.9) was performed for tissue composition measured using HM-MRI and reference standard results from pathologists' consensus.ResultsBased on the initial results showing typical variation among pathologists TDI0.9 = 25%, we determined we will declare acceptable agreement if the 95% one-sided upper confident limit of TDI0.9 is less than 30%. The results of tissue composition measurement from HM-MRI compared to ground truth results from the consensus of 3 pathologists, reveal that ninety percent of absolute paired differences (TDI0.9) were within 18.8% and 22.4% in measuring epithelium and lumen, respectively. We are 95% confident that 90% of absolute paired differences were within 20.6% and 24.2% in measuring epithelium and lumen, respectively. These were less than our criterion of 30% and inter-pathologists' agreement (22.3% for epithelium and 24.2% for lumen) and therefore we accept the agreement performance of HM-MRI. The results revealed excellent area under the ROC curve for differentiating cancer from benign tissue based on epithelium (HM-MRI: 0.87, pathologists: 0.97) and lumen volume (HM-MRI: 0.85, pathologists: 0.77).ConclusionThe agreement in tissue composition measurement using hybrid multidimensional MRI and consensus of pathologists is on par with the inter-raters (pathologists) agreement.

Dataset Information

Do pathologists agree with each other on the histological assessment of pT1b oesophageal adenocarcinoma?

Background

Objective

Methods

Results

Conclusions

Publications

Do pathologists agree with each other on the histological assessment of pT1b oesophageal adenocarcinoma?

Similar Datasets

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